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TitleIL-17-induced dimerization of IL-17RA drives the formation of the IL-17 signalosome to potentiate signaling.
Journal, issue, pagesCell Rep, Vol. 41, Page 111489-111489, Year 2022
Publish dateFeb 24, 2017 (structure data deposition date)
AuthorsGoepfert, A. / Barske, C. / Lehmann, S. / Wirth, E. / Willemsen, J. / Gudjonsson, J.E. / Ward, N.L. / Sarkar, M.K. / Hemmig, R. / Kolbinger, F. / Rondeau, J.M.
External linksCell Rep / PubMed:36260993
MethodsX-ray diffraction
Resolution1.9 - 5.061 Å
Structure data

PDB-5n9b:
Crystal Structure of unliganded human IL-17RA
Method: X-RAY DIFFRACTION / Resolution: 1.9 Å

PDB-7zan:
Crystal Structure of human IL-17A in complex with IL-17RA and IL-17RC
Method: X-RAY DIFFRACTION / Resolution: 5.061 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Fibronectin type III / CYTOKINE / Immune system

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