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TitleSingle-chain insulin analogs threaded by the insulin receptor alpha CT domain.
Journal, issue, pagesBiophys. J., Year 2022
Publish dateOct 8, 2020 (structure data deposition date)
AuthorsSmith, N.A. / Menting, J.G. / Weiss, M.A. / Lawrence, M.C. / Smith, B.J.
External linksBiophys. J. / PubMed:36181268
MethodsX-ray diffraction
Resolution2.6 Å
Structure data

PDB-7kd6:
Insulin Receptor L1-CR plus alphaCT fragment in co-complex with Fv 83-7 and single-chain insulin SCI-b
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • mus musculus (house mouse)
KeywordsSIGNALING PROTEIN / Insulin receptor Single-chain insulin Antibody Fv module Insulin micro-receptor

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