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-Structure paper
タイトル | Cryo-EM structure of human MG53 homodimer. |
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ジャーナル・号・ページ | Biochem J, Vol. 479, Issue 17, Page 1909-1916, Year 2022 |
掲載日 | 2022年9月16日 |
著者 | Yange Niu / Gengjia Chen / Fengxiang Lv / Rui-Ping Xiao / Xinli Hu / Lei Chen / |
PubMed 要旨 | MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a ...MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a 'body' and two 'wings'. Intermolecular interactions are mainly distributed in the 'body' which is relatively stable, while two 'wings' are more dynamic. The overall architecture of MG53 is distinct from those of TRIM20 and TRIM25, illustrating the broad structural diversity of this protein family. |
リンク | Biochem J / PubMed:36053137 |
手法 | EM (単粒子) |
解像度 | 3.5 Å |
構造データ | EMDB-33606, PDB-7y4s: |
由来 |
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キーワード | STRUCTURAL PROTEIN / Tripartite motif-containing protein 72 / MG53 / TRIM72 / Membrane repair / PRY-SPRY domain / Mitsugumin-53 |