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Structure paper

TitleStructural insights into selective inhibition of leishmanial GDP-mannose pyrophosphorylase.
Journal, issue, pagesCell Discov, Vol. 8, Issue 1, Page 83, Year 2022
Publish dateAug 30, 2022
AuthorsHang Li / Tuo Ji / Qi Sun / Yao Chen / Weiya Xu / Chengdong Huang /
External linksCell Discov / PubMed:36038534 / PubMed Central
MethodsEM (single particle)
Resolution3.1 - 3.5 Å
Structure data

32509

7whr

EMDB-32509, PDB-7whr:
Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase
Method: EM (single particle) / Resolution: 3.4 Å

32510

7whs

EMDB-32510, PDB-7whs:
Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase in complex with GTP
Method: EM (single particle) / Resolution: 3.1 Å

32511

7wht

EMDB-32511, PDB-7wht:
Cryo-EM Structure of Leishmanial GDP-mannose pyrophosphorylase in complex with GDP-Mannose
Method: EM (single particle) / Resolution: 3.5 Å

Chemicals

ChemComp-GTP:
GUANOSINE-5'-TRIPHOSPHATE / GTP, energy-carrying molecule*YM

ChemComp-MG:
Unknown entry

ChemComp-GDD:
GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE

Source
  • leishmania donovani (eukaryote)
KeywordsSUGAR BINDING PROTEIN / protozoan enzyme / Leishmania donovani

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