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TitleStructure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity.
Journal, issue, pagesFront Immunol, Vol. 13, Page 872536-872536, Year 2022
Publish dateDec 16, 2021 (structure data deposition date)
AuthorsPedersen, H. / Jensen, R.K. / Hansen, A.G. / Petersen, S.V. / Thiel, S. / Laursen, N.S. / Andersen, G.R.
External linksFront Immunol / PubMed:35935935
MethodsX-ray diffraction
Resolution2.8 Å
Structure data

PDB-7qiv:
Structure of human C3b in complex with the EWE nanobody
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • lama glama (llama)
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / complement / alternative pathway / antibody / nanobody / protein engineering

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