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TitleEnzyme-Catalyzed Spiroacetal Formation in Polyketide Antibiotic Biosynthesis.
Journal, issue, pagesJ. Am. Chem. Soc., Vol. 144, Page 14555-14563, Year 2022
Publish dateOct 4, 2021 (structure data deposition date)
AuthorsBilyk, O. / Oliveira, G.S. / de Angelo, R.M. / Almeida, M.O. / Honorio, K.M. / Leeper, F.J. / Dias, M.V.B. / Leadlay, P.F.
External linksJ. Am. Chem. Soc. / PubMed:35921248
MethodsX-ray diffraction
Resolution2.1 - 2.2 Å
Structure data

PDB-7sfn:
Crystal structure of OlmO, a spirocyclase involved in the biosynthesis of oligomycin
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

PDB-7sfp:
Crystal structure of OssO, a spirocyclase involved in the biosynthesis of ossamycin
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-MLT:
D-MALATE

ChemComp-HOH:
WATER

Source
  • streptomyces avermitilis (bacteria)
  • streptomyces ossamyceticus (bacteria)
KeywordsHYDROLASE / cyclase / spyrocyclase / oligomycin / calycin

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