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Structure paper

TitleStructural basis of human TREX1 DNA degradation and autoimmune disease.
Journal, issue, pagesNat Commun, Vol. 13, Page 4277-4277, Year 2022
Publish dateJan 26, 2022 (structure data deposition date)
AuthorsZhou, W. / Richmond-Buccola, D. / Wang, Q. / Kranzusch, P.J.
External linksNat Commun / PubMed:35879334
MethodsX-ray diffraction
Resolution1.25 - 2.2 Å
Structure data

PDB-7tqn:
Structure of human TREX1
Method: X-RAY DIFFRACTION / Resolution: 1.8 Å

PDB-7tqo:
Structure of human TREX1
Method: X-RAY DIFFRACTION / Resolution: 1.25 Å

PDB-7tqp:
Structure of human TREX1
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7tqq:
Structure of human TREX1-DNA complex
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsHYDROLASE / nuclease / DNase / innate immunity / autoimmunity / HYDROLASE/DNA / HYDROLASE-DNA complex

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