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TitleQualitative differences in disease-associated MEK mutants reveal molecular signatures and aberrant signaling-crosstalk in cancer.
Journal, issue, pagesNat Commun, Vol. 13, Page 4063-4063, Year 2022
Publish dateJun 15, 2021 (structure data deposition date)
AuthorsKubota, Y. / Fujioka, Y. / Patil, A. / Takagi, Y. / Matsubara, D. / Iijima, M. / Momose, I. / Naka, R. / Nakai, K. / Noda, N.N. / Takekawa, M.
External linksNat Commun / PubMed:35831322
MethodsX-ray diffraction
Resolution2.007 Å
Structure data

PDB-7f2x:
Crystal structure of MEK1 C121S mutant
Method: X-RAY DIFFRACTION / Resolution: 2.007 Å

Chemicals

ChemComp-ANP:
PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / AMP-PNP, energy-carrying molecule analogue*YM

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Kinase

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