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TitleEnhanced polymerase activity permits efficient synthesis by cancer-associated DNA polymerase ε variants at low dNTP levels.
Journal, issue, pagesNucleic Acids Res., Vol. 50, Page 8023-8040, Year 2022
Publish dateFeb 8, 2022 (structure data deposition date)
AuthorsBarbari, S.R. / Beach, A.K. / Markgren, J.G. / Parkash, V. / Moore, E.A. / Johansson, E. / Shcherbakova, P.V.
External linksNucleic Acids Res. / PubMed:35822874
MethodsX-ray diffraction
Resolution2.46 - 2.6 Å
Structure data

PDB-7r3x:
The crystal structure of the L439V variant of Pol2CORE in complex with DNA and an incoming nucleotide
Method: X-RAY DIFFRACTION / Resolution: 2.46 Å

PDB-7r3y:
The crystal structure of the V426L variant of Pol2CORE in complex with DNA and an incoming nucleotide
Method: X-RAY DIFFRACTION / Resolution: 2.6 Å

Chemicals

ChemComp-DTP:
2'-DEOXYADENOSINE 5'-TRIPHOSPHATE

ChemComp-CA:
Unknown entry

ChemComp-ACT:
ACETATE ION

ChemComp-HOH:
WATER

Source
  • saccharomyces cerevisiae (brewer's yeast)
  • synthetic construct (others)
KeywordsDNA BINDING PROTEIN / protein-DNA complex

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