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Structure paper

TitleEvolution and activation mechanism of the flavivirus class II membrane-fusion machinery.
Journal, issue, pagesNat Commun, Vol. 13, Page 3718-3718, Year 2022
Publish dateJan 11, 2022 (structure data deposition date)
AuthorsVaney, M.C. / Dellarole, M. / Duquerroy, S. / Medits, I. / Tsouchnikas, G. / Rouvinski, A. / England, P. / Stiasny, K. / Heinz, F.X. / Rey, F.A.
External linksNat Commun / PubMed:35764616
MethodsX-ray diffraction
Resolution2.28 - 2.8 Å
Structure data

PDB-7qre:
Structure of the hetero-tetramer complex between precursor membrane protein fragment (pr) and envelope protein (E) from tick-borne encephalitis virus
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7qrf:
Structure of the dimeric complex between precursor membrane ectodomain (prM) and envelope protein ectodomain (E) from tick-borne encephalitis virus
Method: X-RAY DIFFRACTION / Resolution: 2.28 Å

PDB-7qrg:
Structure of the post-fusion complex between precursor membrane ectodomain (prM) and envelope ectodomain protein (E) from tick-borne encephalitis virus
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

ChemComp-PE4:
2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL / precipitant*YM

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-GOL:
GLYCEROL

Source
  • tick-borne encephalitis virus (western subtype)
KeywordsVIRAL PROTEIN / class II fusion envelope protein / precursor membrane protein / chaperone / flavivirus maturation / trans-golgi acid pH / post-fusion / flavivirus

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