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TitleA bioactive phlebovirus-like envelope protein in a hookworm endogenous virus.
Journal, issue, pagesSci Adv, Vol. 8, Issue 19, Page eabj6894, Year 2022
Publish dateMay 13, 2022
AuthorsMonique Merchant / Carlos P Mata / Yangci Liu / Haoming Zhai / Anna V Protasio / Yorgo Modis /
PubMed AbstractEndogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus ...Endogenous viral elements (EVEs), accounting for 15% of our genome, serve as a genetic reservoir from which new genes can emerge. Nematode EVEs are particularly diverse and informative of virus evolution. We identify Atlas virus-an intact retrovirus-like EVE in the human hookworm , with an envelope protein genetically related to G-G glycoproteins from the family Phenuiviridae. A cryo-EM structure of Atlas G reveals a class II viral membrane fusion protein fold not previously seen in retroviruses. Atlas G has the structural hallmarks of an active fusogen. Atlas G trimers insert into membranes with endosomal lipid compositions and low pH. When expressed on the plasma membrane, Atlas G has cell-cell fusion activity. With its preserved biological activities, Atlas G has the potential to acquire a cellular function. Our work reveals structural plasticity in reverse-transcribing RNA viruses.
External linksSci Adv / PubMed:35544562 / PubMed Central
MethodsEM (single particle)
Resolution3.76 Å
Structure data

11630

7a4a

EMDB-11630, PDB-7a4a:
Envelope glycprotein of endogenous retrovirus Y032 (Atlas virus) from the human hookworm Ancylostoma ceylanicum
Method: EM (single particle) / Resolution: 3.76 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • ancylostoma ceylanicum (invertebrata)
KeywordsVIRAL PROTEIN / class II membrane fusion protein; retroviral envelope protein (Env); lipid binding protein; disulfide bonding

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