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Structure paper

TitleStructural insights into Charcot-Marie-Tooth disease-linked mutations in human GDAP1.
Journal, issue, pagesFebs Open Bio, Vol. 12, Page 1306-1324, Year 2022
Publish dateNov 8, 2021 (structure data deposition date)
AuthorsSutinen, A. / Nguyen, G.T.T. / Raasakka, A. / Muruganandam, G. / Loris, R. / Ylikallio, E. / Tyynismaa, H. / Bartesaghi, L. / Ruskamo, S. / Kursula, P.
External linksFebs Open Bio / PubMed:35509130
MethodsX-ray diffraction
Resolution2.2 - 3.41 Å
Structure data

PDB-7q6j:
Crystal structure of the human GDAP1 CMT2 mutant-H123R
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7q6k:
Crystal structure of the human GDAP1 CMT2 mutant-R120W
Method: X-RAY DIFFRACTION / Resolution: 3.41 Å

PDB-7ywd:
Human GDAP1 core domain, trigonal crystal form
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / Charcot-Marie-Tooth / CMT2 / Mutation / Mitochondria / MEMBRANE PROTEIN / GST homology / mitochondrial outer membrane / Charcot-Marie-Tooth disease

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