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TitleCharacterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain.
Journal, issue, pagesSci Adv, Vol. 8, Page eabm3948-eabm3948, Year 2022
Publish dateJul 12, 2021 (structure data deposition date)
AuthorsGray, M.D. / Feng, J. / Weidle, C.E. / Cohen, K.W. / Ballweber-Fleming, L. / MacCamy, A.J. / Huynh, C.N. / Trichka, J.J. / Montefiori, D. / Ferrari, G. ...Gray, M.D. / Feng, J. / Weidle, C.E. / Cohen, K.W. / Ballweber-Fleming, L. / MacCamy, A.J. / Huynh, C.N. / Trichka, J.J. / Montefiori, D. / Ferrari, G. / Pancera, M. / McElrath, M.J. / Stamatatos, L.
External linksSci Adv / PubMed:35507661
MethodsX-ray diffraction
Resolution3.55 Å
Structure data

PDB-7rdw:
Crystal Structure of FH1 Fab bound to HXb2 HIV-1 gp120 core
Method: X-RAY DIFFRACTION / Resolution: 3.55 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NH4:
AMMONIUM ION

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • human immunodeficiency virus 1
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / FH1 / VH1-2*02 / VRC01 / Antibody / HIV-1

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