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-Structure paper
タイトル | Formation of thyroid hormone revealed by a cryo-EM structure of native bovine thyroglobulin. |
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ジャーナル・号・ページ | Nat Commun, Vol. 13, Issue 1, Page 2380, Year 2022 |
掲載日 | 2022年5月2日 |
著者 | Nils Marechal / Banyuhay P Serrano / Xinyan Zhang / Charles J Weitz / |
PubMed 要旨 | Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa ...Thyroid hormones are essential regulators of metabolism, development, and growth. They are formed from pairs of iodinated tyrosine residues within the precursor thyroglobulin (TG), a 660-kDa homodimer of the thyroid gland, by an oxidative coupling reaction. Tyrosine pairs that give rise to thyroid hormones have been assigned within the structure of human TG, but the process of hormone formation is poorly understood. Here we report a ~3.3-Å cryo-EM structure of native bovine TG with nascent thyroid hormone formed at one of the predicted hormonogenic sites. Local structural rearrangements provide insight into mechanisms underlying thyroid hormone formation and stabilization. |
リンク | Nat Commun / PubMed:35501346 / PubMed Central |
手法 | EM (単粒子) |
解像度 | 3.3 Å |
構造データ | EMDB-14145, PDB-7qtq: |
化合物 | ChemComp-NAG: |
由来 |
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キーワード | HORMONE / Thyroglobulin / thyroid hormone / iodine / precursor |