+Search query
-Structure paper
Title | Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor. |
---|---|
Journal, issue, pages | J. Med. Chem., Vol. 65, Page 6513-6540, Year 2022 |
Publish date | Sep 30, 2021 (structure data deposition date) |
Authors | Miller, D.C. / Reuillon, T. / Molyneux, L. / Blackburn, T. / Cook, S.J. / Edwards, N. / Endicott, J.A. / Golding, B.T. / Griffin, R.J. / Hardcastle, I. ...Miller, D.C. / Reuillon, T. / Molyneux, L. / Blackburn, T. / Cook, S.J. / Edwards, N. / Endicott, J.A. / Golding, B.T. / Griffin, R.J. / Hardcastle, I. / Harnor, S.J. / Heptinstall, A. / Lochhead, P. / Martin, M.P. / Martin, N.C. / Myers, S. / Newell, D.R. / Noble, R.A. / Phillips, N. / Rigoreau, L. / Thomas, H. / Tucker, J.A. / Wang, L.Z. / Waring, M.J. / Wong, A.C. / Wedge, S.R. / Noble, M.E.M. / Cano, C. |
External links | J. Med. Chem. / PubMed:35468293 |
Methods | X-ray diffraction |
Resolution | 2.59 Å |
Structure data | PDB-7pus: |
Chemicals | ChemComp-86E: ChemComp-HOH: |
Source |
|
Keywords | TRANSFERASE / KINASE / INHIBITOR / PYRROLE |