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TitleAtomic Structures of Coxsackievirus B5 Provide Key Information on Viral Evolution and Survival.
Journal, issue, pagesJ Virol, Vol. 96, Issue 9, Page e0010522, Year 2022
Publish dateMay 11, 2022
AuthorsPeng Yang / Dawei Shi / Jianmeng Fu / Li Zhang / Ruihong Chen / Binyang Zheng / Xiangxi Wang / Sihong Xu / Ling Zhu / Kang Wang /
PubMed AbstractCoxsackie virus B5 (CVB5), a main serotype in human Enterovirus B (EVB), can cause severe viral encephalitis and aseptic meningitis among infants and children. Currently, there is no approved vaccine ...Coxsackie virus B5 (CVB5), a main serotype in human Enterovirus B (EVB), can cause severe viral encephalitis and aseptic meningitis among infants and children. Currently, there is no approved vaccine or antiviral therapy available against CVB5 infection. Here, we determined the atomic structures of CVB5 in three forms: mature full (F) particle (2.73 Å), intermediate altered (A) particle (2.81 Å), and procapsid empty (E) particle (2.95 Å). Structural analysis of F particle of CVB5 unveiled similar structures of "canyon," "puff," and "knob" as those other EV-Bs. We observed structural rearrangements that are alike during the transition from F to A particle, indicative of similar antigenicity, cell entry, and uncoating mechanisms shared by all EV-Bs. Further comparison of structures and sequences among all structure-known EV-Bs revealed that while the residues targeted by neutralizing MAbs are diversified and drive the evolution of EV-Bs, the relative conserved residues recognized by uncoating receptors could serve as the basis for the development of antiviral vaccines and therapeutics. As one of the main serotypes in Enterovirus B, CVB5 has been commonly reported in recent years. The atomic structures of CVB5 shown here revealed classical features found in EV-Bs and the structural rearrangement occurring during particle expansion and uncoating. Also, structure- and sequence-based comparison between CVB5 and other structure-known EV-Bs screened out key domains important for viral evolution and survival. All these provide insights into the development of vaccine and therapeutics for EV-Bs.
External linksJ Virol / PubMed:35442060 / PubMed Central
MethodsEM (single particle)
Resolution2.81 - 2.95 Å
Structure data

32575

7wl3

EMDB-32575, PDB-7wl3:
CVB5 expended empty particle
Method: EM (single particle) / Resolution: 2.95 Å

33101

7xb2

EMDB-33101, PDB-7xb2:
CVB5-intermediate altered particle containing VP1/VP2/VP3 and RNA genome
Method: EM (single particle) / Resolution: 2.81 Å

Source
  • coxsackievirus b5
KeywordsVIRUS / CVB5 E-particle / Coxsackie virus B5 / intermediate altered particle

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