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TitleTrapping and structural characterisation of a covalent intermediate in vitamin B 6 biosynthesis catalysed by the Pdx1 PLP synthase.
Journal, issue, pagesRsc Chem Biol, Vol. 3, Page 227-230, Year 2022
Publish dateFeb 10, 2021 (structure data deposition date)
AuthorsRodrigues, M.J. / Giri, N. / Royant, A. / Zhang, Y. / Bolton, R. / Evans, G. / Ealick, S.E. / Begley, T. / Tews, I.
External linksRsc Chem Biol / PubMed:35360887
MethodsX-ray diffraction
Resolution2.23 - 2.35 Å
Structure data

PDB-7nhe:
Crystal structure of Arabidopsis thaliana Pdx1K166R-I333 complex
Method: X-RAY DIFFRACTION / Resolution: 2.23 Å

PDB-7nhf:
Crystal structure of Arabidopsis thaliana Pdx1K166R
Method: X-RAY DIFFRACTION / Resolution: 2.35 Å

Chemicals

ChemComp-PO4:
PHOSPHATE ION

ChemComp-KPR:
[(~{E},4~{S})-4-azanyl-3-oxidanylidene-pent-1-enyl] dihydrogen phosphate

ChemComp-HOH:
WATER

Source
  • arabidopsis thaliana (thale cress)
KeywordsLYASE / VITAMIN B6 BIOSYTHESIS / PLP SYNTHASE / PDX1

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