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TitleEnzymatic assembly of the salinosporamide gamma-lactam-beta-lactone anticancer warhead.
Journal, issue, pagesNat. Chem. Biol., Vol. 18, Page 538-546, Year 2022
Publish dateSep 4, 2021 (structure data deposition date)
AuthorsBauman, K.D. / Shende, V.V. / Chen, P.Y. / Trivella, D.B.B. / Gulder, T.A.M. / Vellalath, S. / Romo, D. / Moore, B.S.
External linksNat. Chem. Biol. / PubMed:35314816
MethodsX-ray diffraction
Resolution2.85 Å
Structure data

PDB-7s2x:
Structure of SalC, a gamma-lactam-beta-lactone bicyclase for salinosporamide biosynthesis
Method: X-RAY DIFFRACTION / Resolution: 2.85 Å

Chemicals

ChemComp-K:
Unknown entry

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

Source
  • salinispora tropica (bacteria)
KeywordsBIOSYNTHETIC PROTEIN / salinosporamide / Marizomib / bicyclase / cyclase / lactam / lactone / ketosynthase / TRANSFERASE

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