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-Structure paper
Title | Cryo-EM Structure of a Possum Enterovirus. |
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Journal, issue, pages | Viruses, Vol. 14, Issue 2, Year 2022 |
Publish date | Feb 3, 2022 |
Authors | Ivy Wang / Sandeep K Gupta / Guillaume Ems / Nadishka Jayawardena / Mike Strauss / Mihnea Bostina / |
PubMed Abstract | Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess ...Enteroviruses (EVs) represent a substantial concern to global health. Here, we present the cryo-EM structure of a non-human enterovirus, EV-F4, isolated from the Australian brushtail possum to assess the structural diversity of these picornaviruses. The capsid structure, determined to ~3 Å resolution by single particle analysis, exhibits a largely smooth surface, similar to EV-F3 (formerly BEV-2). Although the cellular receptor is not known, the absence of charged residues on the outer surface of the canyon suggest a different receptor type than for EV-F3. Density for the pocket factor is clear, with the entrance to the pocket being smaller than for other enteroviruses. |
External links | Viruses / PubMed:35215909 / PubMed Central |
Methods | EM (single particle) |
Resolution | 2.96 Å |
Structure data | EMDB-25905, PDB-7thx: |
Chemicals | ChemComp-SPH: ChemComp-K: ChemComp-HOH: |
Source |
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Keywords | VIRUS / enterovirus / icosahedral |