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TitleA highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease.
Journal, issue, pagesCell Chem Biol, Vol. 29, Page 947-957.e8, Year 2022
Publish dateJan 11, 2021 (structure data deposition date)
AuthorsDouglas, L.E.J. / Reihill, J.A. / Ho, M.W.Y. / Axten, J.M. / Campobasso, N. / Schneck, J.L. / Rendina, A.R. / Wilcoxen, K.M. / Martin, S.L.
External linksCell Chem Biol / PubMed:35202587
MethodsX-ray diffraction
Resolution1.24 Å
Structure data

PDB-7lcu:
X-ray structure of Furin bound to BOS-318, a small molecule inhibitor
Method: X-RAY DIFFRACTION / Resolution: 1.24 Å

Chemicals

ChemComp-CA:
Unknown entry

ChemComp-XTA:
(1-{[2-(3,5-dichlorophenyl)-6-{[2-(4-methylpiperazin-1-yl)pyrimidin-5-yl]oxy}pyridin-4-yl]methyl}piperidin-4-yl)acetic acid

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsHYDROLASE/INHIBITOR / Inhibitor protease / HYDROLASE-INHIBITOR complex

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