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-Structure paper
Title | Glioblastoma mutations alter EGFR dimer structure to prevent ligand bias. |
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Journal, issue, pages | Nature, Vol. 602, Page 518-522, Year 2022 |
Publish date | Jan 14, 2021 (structure data deposition date) |
![]() | Hu, C. / Leche 2nd, C.A. / Kiyatkin, A. / Yu, Z. / Stayrook, S.E. / Ferguson, K.M. / Lemmon, M.A. |
![]() | ![]() ![]() |
Methods | X-ray diffraction |
Resolution | 2.9 - 3.5 Å |
Structure data | ![]() PDB-7len: ![]() PDB-7lfr: ![]() PDB-7lfs: |
Chemicals | ![]() ChemComp-NAG: ![]() ChemComp-MAN: ![]() ChemComp-BMA: |
Source |
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![]() | SIGNALING PROTEIN / receptor / epiregulin / glioblastoma / cancer / mutation / extracellular / asymmetric / dimer / ErbB1 / EGFR |