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Structure paper

TitleGlioblastoma mutations alter EGFR dimer structure to prevent ligand bias.
Journal, issue, pagesNature, Vol. 602, Page 518-522, Year 2022
Publish dateJan 14, 2021 (structure data deposition date)
AuthorsHu, C. / Leche 2nd, C.A. / Kiyatkin, A. / Yu, Z. / Stayrook, S.E. / Ferguson, K.M. / Lemmon, M.A.
External linksNature / PubMed:35140400
MethodsX-ray diffraction
Resolution2.9 - 3.5 Å
Structure data

PDB-7len:
Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with trehalose
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-7lfr:
Crystal structure of the epidermal growth factor receptor extracellular region with R84K mutation in complex with epiregulin crystallized with spermine
Method: X-RAY DIFFRACTION / Resolution: 3.2 Å

PDB-7lfs:
Crystal structure of the epidermal growth factor receptor extracellular region with A265V mutation in complex with epiregulin
Method: X-RAY DIFFRACTION / Resolution: 3.5 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MAN:
alpha-D-mannopyranose

ChemComp-BMA:
beta-D-mannopyranose

Source
  • homo sapiens (human)
KeywordsSIGNALING PROTEIN / receptor / epiregulin / glioblastoma / cancer / mutation / extracellular / asymmetric / dimer / ErbB1 / EGFR

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