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TitleTwo diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor.
Journal, issue, pagesSci Adv, Vol. 8, Page eabl7872-eabl7872, Year 2022
Publish dateDec 2, 2021 (structure data deposition date)
AuthorsWelcker, M. / Wang, B. / Rusnac, D.V. / Hussaini, Y. / Swanger, J. / Zheng, N. / Clurman, B.E.
External linksSci Adv / PubMed:35089787
MethodsX-ray diffraction
Resolution2.55 - 2.77 Å
Structure data

PDB-7t1y:
Structure of the Fbw7-Skp1-MycCdegron complex
Method: X-RAY DIFFRACTION / Resolution: 2.55 Å

PDB-7t1z:
Structure of the Fbw7-Skp1-MycNdegron complex
Method: X-RAY DIFFRACTION / Resolution: 2.77 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsLIGASE / Ubiquitin ligase / WD40

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