タイトル | Structure-based discovery of nonhallucinogenic psychedelic analogs. |
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ジャーナル・号・ページ | Science, Vol. 375, Page 403-411, Year 2022 |
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掲載日 | 2021年12月18日 (構造データの登録日) |
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著者 | Cao, D. / Yu, J. / Wang, H. / Luo, Z. / Liu, X. / He, L. / Qi, J. / Fan, L. / Tang, L. / Chen, Z. ...Cao, D. / Yu, J. / Wang, H. / Luo, Z. / Liu, X. / He, L. / Qi, J. / Fan, L. / Tang, L. / Chen, Z. / Li, J. / Cheng, J. / Wang, S. |
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リンク | Science / PubMed:35084960 |
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手法 | X線回折 |
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解像度 | 2.45 - 3.2 Å |
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構造データ | PDB-7wc4: Crystal structure of serotonin 2A receptor in complex with serotonin 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-7wc5: Crystal structure of serotonin 2A receptor in complex with psilocin 手法: X-RAY DIFFRACTION / 解像度: 3.2 Å PDB-7wc6: Crystal structure of serotonin 2A receptor in complex with LSD 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7wc7: Crystal structure of serotonin 2A receptor in complex with lisuride 手法: X-RAY DIFFRACTION / 解像度: 2.6 Å PDB-7wc8: Crystal structure of serotonin 2A receptor in complex with lumateperone 手法: X-RAY DIFFRACTION / 解像度: 2.45 Å PDB-7wc9: Crystal structure of serotonin 2A receptor in complex with non-hallucinogenic psychedelic analog 手法: X-RAY DIFFRACTION / 解像度: 2.5 Å |
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化合物 | ChemComp-91Q: 3-[2-(dimethylamino)ethyl]-1~{H}-indol-4-ol / プシロシン / alkaloid*YM
ChemComp-7LD: (8alpha)-N,N-diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide / LSD
ChemComp-H8G: N,N-diethyl-N'-[(8alpha)-6-methyl-9,10-didehydroergolin-8-yl]urea / リスリド / 薬剤*YM
ChemComp-92S: 1-(4-fluorophenyl)-4-[(10~{R},15~{S})-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5,7,9(16)-trien-12-yl]butan-1-one / 1-(4-フルオロフェニル)-4-[(6bR,10aS)-3-メチル-2,3,6b,9,10,10a-ヘキサヒドロ-1(以下略) / 薬剤, 抗精神病薬*YM
ChemComp-93F: (10~{R},15~{S})-12-[3-(2-methoxyphenyl)propyl]-4-methyl-1,4,12-triazatetracyclo[7.6.1.0^{5,16}.0^{10,15}]hexadeca-5(16),6,8-triene
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由来 | - homo sapiens (ヒト)
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キーワード | MEMBRANE PROTEIN / serotonin 2A receptor / serotonin / 5-HT / psilocin / psilocybin / LSD / lisuride / Lumateperone / non-hallucinogenic psychedelic |
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