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TitleStructural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 202, Page 529-538, Year 2022
Publish dateJan 12, 2022 (structure data deposition date)
AuthorsXu, J.G. / Jia, H. / Chen, S. / Xu, J. / Zhan, Y. / Yu, H. / Wang, W. / Kang, X. / Cui, X. / Feng, Y. ...Xu, J.G. / Jia, H. / Chen, S. / Xu, J. / Zhan, Y. / Yu, H. / Wang, W. / Kang, X. / Cui, X. / Feng, Y. / Chen, X. / Xu, W. / Pan, X. / Wei, X. / Li, H. / Wang, Y. / Xia, S. / Liu, X. / Yang, L. / He, Y. / Zhu, X.
External linksInt. J. Biol. Macromol. / PubMed:35066019
MethodsX-ray diffraction
Resolution2.81 Å
Structure data

PDB-7wkx:
IL-17A in complex with the humanized antibody HB0017
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-MLA:
MALONIC ACID

ChemComp-ACY:
ACETIC ACID

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsCYTOKINE / HB0017 / IL17A / monoclonal antibody / complex

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