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TitleIdentification of a diarylpentanoid-producing polyketide synthase revealing an unusual biosynthetic pathway of 2-(2-phenylethyl)chromones in agarwood.
Journal, issue, pagesNat Commun, Vol. 13, Page 348-348, Year 2022
Publish dateJul 23, 2021 (structure data deposition date)
AuthorsWang, X.H. / Gao, B.W. / Nakashima, Y. / Mori, T. / Zhang, Z.X. / Kodama, T. / Lee, Y.E. / Zhang, Z.K. / Wong, C.P. / Liu, Q.Q. ...Wang, X.H. / Gao, B.W. / Nakashima, Y. / Mori, T. / Zhang, Z.X. / Kodama, T. / Lee, Y.E. / Zhang, Z.K. / Wong, C.P. / Liu, Q.Q. / Qi, B.W. / Wang, J. / Li, J. / Liu, X. / Abe, I. / Morita, H. / Tu, P.F. / Shi, S.P.
External linksNat Commun / PubMed:35039506
MethodsX-ray diffraction
Resolution1.98 - 2.61 Å
Structure data

PDB-7ffa:
Diarylpentanoid-producing polyketide synthase from Aquilaria sinensis
Method: X-RAY DIFFRACTION / Resolution: 1.98 Å

PDB-7ffc:
Diarylpentanoid-producing polyketide synthase (A210E mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.61 Å

PDB-7ffg:
Diarylpentanoid-producing polyketide synthase (N199F mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.3 Å

PDB-7ffh:
Diarylpentanoid-producing polyketide synthase (N199L mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7ffi:
Diarylpentanoid-producing polyketide synthase (F340W mutant)
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-GOL:
GLYCEROL

Source
  • aquilaria sinensis (plant)
KeywordsTRANSFERASE / diarylpentanoid / type-III polyketide synthase

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