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Title | Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. |
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Journal, issue, pages | Nat Commun, Vol. 13, Page 136-136, Year 2022 |
Publish date | Oct 19, 2020 (structure data deposition date) |
Authors | Zhang, J. / Walker, M.E. / Sanidad, K.Z. / Zhang, H. / Liang, Y. / Zhao, E. / Chacon-Vargas, K. / Yeliseyev, V. / Parsonnet, J. / Haggerty, T.D. ...Zhang, J. / Walker, M.E. / Sanidad, K.Z. / Zhang, H. / Liang, Y. / Zhao, E. / Chacon-Vargas, K. / Yeliseyev, V. / Parsonnet, J. / Haggerty, T.D. / Wang, G. / Simpson, J.B. / Jariwala, P.B. / Beaty, V.V. / Yang, J. / Yang, H. / Panigrahy, A. / Minter, L.M. / Kim, D. / Gibbons, J.G. / Liu, L. / Li, Z. / Xiao, H. / Borlandelli, V. / Overkleeft, H.S. / Cloer, E.W. / Major, M.B. / Goldfarb, D. / Cai, Z. / Redinbo, M.R. / Zhang, G. |
External links | Nat Commun / PubMed:35013263 |
Methods | X-ray diffraction |
Resolution | 2.2 - 2.4 Å |
Structure data | PDB-7kgy: PDB-7kgz: |
Chemicals | ChemComp-I9G: ChemComp-GOL: ChemComp-HOH: ChemComp-CA: ChemComp-FMN: |
Source |
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Keywords | HYDROLASE/INHIBITOR / Beta-glucuronidase / carbohydrate / glucuronic acid / inhibitor / HYDROLASE / HYDROLASE-INHIBITOR complex / gut microbial enzyme / FMN |