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Structure paper

TitleCrystal structure and functional implication of bacterial STING.
Journal, issue, pagesNat Commun, Vol. 13, Page 26-26, Year 2022
Publish dateMar 9, 2021 (structure data deposition date)
AuthorsKo, T.-P. / Wang, Y.-C. / Yang, C.-S. / Hou, M.-H. / Chen, C.-J. / Chiu, Y.-F. / Chen, Y.
External linksNat Commun / PubMed:35013136
MethodsX-ray diffraction
Resolution2.17 - 2.25 Å
Structure data

PDB-7ebd:
Bacterial STING in complex with c-di-GMP
Method: X-RAY DIFFRACTION / Resolution: 2.25 Å

PDB-7ebl:
Bacterial STING in complex with c-di-GMP
Method: X-RAY DIFFRACTION / Resolution: 2.17 Å

Chemicals

ChemComp-ACT:
ACETATE ION

ChemComp-C2E:
9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one)

ChemComp-HOH:
WATER

Source
  • prevotella corporis (bacteria)
  • myroides sp. zb35 (bacteria)
KeywordsSIGNALING PROTEIN / second messenger / complex / cyclic dinucleotide / antiviral pathway

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