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TitleDual-Mechanism Confers Self-Resistance to the Antituberculosis Antibiotic Capreomycin.
Journal, issue, pagesAcs Chem. Biol., Vol. 17, Page 138-146, Year 2022
Publish dateJun 3, 2021 (structure data deposition date)
AuthorsPan, Y.C. / Wang, Y.L. / Toh, S.I. / Hsu, N.S. / Lin, K.H. / Xu, Z. / Huang, S.C. / Wu, T.K. / Li, T.L. / Chang, C.Y.
External linksAcs Chem. Biol. / PubMed:34994196
MethodsX-ray diffraction
Resolution1.95 - 2.14 Å
Structure data

PDB-7f0a:
Crystal structure of capreomycin phosphotransferase
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7f0b:
Crystal structure of capreomycin phosphotransferase in complex with ATP
Method: X-RAY DIFFRACTION / Resolution: 2.14 Å

PDB-7f0c:
Crystal structure of capreomycin phosphotransferase in complex with CMN IIA
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

PDB-7f0f:
Crystal structure of capreomycin phosphotransferase in complex with CMN IIB
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-HOH:
WATER

ChemComp-ATP:
ADENOSINE-5'-TRIPHOSPHATE / ATP, energy-carrying molecule*YM

Source
  • saccharothrix mutabilis subsp. capreolus (bacteria)
KeywordsTRANSFERASE / Cph / phosphotransferase / capreomycin / resistance

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