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TitleAnalysis of antibodies from HCV elite neutralizers identifies genetic determinants of broad neutralization.
Journal, issue, pagesImmunity, Vol. 55, Page 341-354.e7, Year 2022
Publish dateJul 14, 2021 (structure data deposition date)
AuthorsWeber, T. / Potthoff, J. / Bizu, S. / Labuhn, M. / Dold, L. / Schoofs, T. / Horning, M. / Ercanoglu, M.S. / Kreer, C. / Gieselmann, L. ...Weber, T. / Potthoff, J. / Bizu, S. / Labuhn, M. / Dold, L. / Schoofs, T. / Horning, M. / Ercanoglu, M.S. / Kreer, C. / Gieselmann, L. / Vanshylla, K. / Langhans, B. / Janicki, H. / Stroh, L.J. / Knops, E. / Nierhoff, D. / Spengler, U. / Kaiser, R. / Bjorkman, P.J. / Krey, T. / Bankwitz, D. / Pfeifer, N. / Pietschmann, T. / Flyak, A.I. / Klein, F.
External linksImmunity / PubMed:34990590
MethodsX-ray diffraction
Resolution2.7 - 3.24 Å
Structure data

PDB-7rfb:
Crystal structure of broadly neutralizing antibody mAb1198 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Method: X-RAY DIFFRACTION / Resolution: 2.7 Å

PDB-7rfc:
Crystal structure of broadly neutralizing antibody mAb1382 in complex with Hepatitis C virus envelope glycoprotein E2 ectodomain
Method: X-RAY DIFFRACTION / Resolution: 3.24 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • homo sapiens (human)
  • hepacivirus c
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / HCV glycoprotein / broadly neutralizing antibodies / VIRAL PROTEIN-IMMUNE SYSTEM complex

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