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Structure paper

TitleStructural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2.
Journal, issue, pagesElife, Vol. 10, Year 2021
Publish dateFeb 15, 2021 (structure data deposition date)
AuthorsFeng, J. / Dong, X. / DeCosta, A. / Su, Y. / Angrisano, F. / Sala, K.A. / Blagborough, A.M. / Lu, C. / Springer, T.A.
External linksElife / PubMed:34939934
MethodsX-ray diffraction
Resolution2.1 - 2.8 Å
Structure data

PDB-7lr3:
Complex of Fab 2/6.14 with domain 3 of P. berghei HAP2
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-7lr4:
Complex of Fab 2/1.12 with domain 3 of P. berghei HAP2
Method: X-RAY DIFFRACTION / Resolution: 2.1 Å

Chemicals

ChemComp-PEG:
DI(HYDROXYETHYL)ETHER

ChemComp-EPE:
4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID / pH buffer*YM

ChemComp-HOH:
WATER

ChemComp-SO4:
SULFATE ION

ChemComp-MES:
2-(N-MORPHOLINO)-ETHANESULFONIC ACID / pH buffer*YM

Source
  • mus musculus (house mouse)
  • plasmodium berghei (eukaryote)
KeywordsSURFACTANT PROTEIN/IMMUNE SYSTEM / transmission-blocking malaria vaccine / membrane fusion / gamete fusogen / monoclonal antibody / SURFACTANT PROTEIN / SURFACTANT PROTEIN-IMMUNE SYSTEM complex / CELL ADHESION/IMMUNE SYSTEM / CELL ADHESION / CELL ADHESION-IMMUNE SYSTEM complex

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