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Structure paper

TitleNeurotoxin-mediated potent activation of the axon degeneration regulator SARM1.
Journal, issue, pagesElife, Vol. 10, Year 2021
Publish dateMar 25, 2021 (structure data deposition date)
AuthorsLoreto, A. / Angeletti, C. / Gu, W. / Osborne, A. / Nieuwenhuis, B. / Gilley, J. / Merlini, E. / Arthur-Farraj, P. / Amici, A. / Luo, Z. ...Loreto, A. / Angeletti, C. / Gu, W. / Osborne, A. / Nieuwenhuis, B. / Gilley, J. / Merlini, E. / Arthur-Farraj, P. / Amici, A. / Luo, Z. / Hartley-Tassell, L. / Ve, T. / Desrochers, L.M. / Wang, Q. / Kobe, B. / Orsomando, G. / Coleman, M.P.
External linksElife / PubMed:34870595
MethodsX-ray diffraction
Resolution1.69 Å
Structure data

PDB-7m6k:
Crystal structure of the ARM domain from Drosophila SARM1 in complex with VMN
Method: X-RAY DIFFRACTION / Resolution: 1.69 Å

Chemicals

ChemComp-YRJ:
3-({[(4-nitrophenyl)carbamoyl]amino}methyl)-1-(5-O-phosphono-beta-D-ribofuranosyl)pyridin-1-ium

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

Source
  • drosophila melanogaster (fruit fly)
KeywordsIMMUNE SYSTEM / neurotoxicity / axon degeneration / NADase / ARM domain

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