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TitleA Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease.
Journal, issue, pagesJ Immunol Res, Vol. 2021, Page 6234836-6234836, Year 2021
Publish dateApr 10, 2018 (structure data deposition date)
AuthorsEbner, F. / Lindner, K. / Janek, K. / Niewienda, A. / Malecki, P.H. / Weiss, M.S. / Sutherland, T.E. / Heuser, A. / Kuhl, A.A. / Zentek, J. ...Ebner, F. / Lindner, K. / Janek, K. / Niewienda, A. / Malecki, P.H. / Weiss, M.S. / Sutherland, T.E. / Heuser, A. / Kuhl, A.A. / Zentek, J. / Hofmann, A. / Hartmann, S.
External linksJ Immunol Res / PubMed:34869783
MethodsX-ray diffraction
Resolution1.74 - 2.69 Å
Structure data

PDB-6g9c:
Crystal structure of immunomodulatory active chitinase from Trichuris suis, TsES1
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

PDB-6g9e:
Crystal structure of immunomodulatory active chitinase from Trichuris suis - TsES1 - 6 molecules in ASU
Method: X-RAY DIFFRACTION / Resolution: 2.69 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

Source
  • trichuris suis (pig whipworm)
KeywordsHYDROLASE / TsES1 / immunomodulatory potential / chitinase / Eukaryotic protein expression / LEXSY / secretion / dimer / intramolecular disulphide bridge / Trichuris suis

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