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TitleInsight on molecular pathogenesis and pharmacochaperoning potential in phosphomannomutase 2 deficiency, provided by novel human phosphomannomutase 2 structures.
Journal, issue, pagesJ Inherit Metab Dis, Vol. 45, Page 318-333, Year 2022
Publish dateMar 26, 2021 (structure data deposition date)
AuthorsBriso-Montiano, A. / Del Cano-Ochoa, F. / Vilas, A. / Velazquez-Campoy, A. / Rubio, V. / Perez, B. / Ramon-Maiques, S.
External linksJ Inherit Metab Dis / PubMed:34859900
MethodsX-ray diffraction
Resolution1.97 - 3.08 Å
Structure data

PDB-7o0c:
Human phosphomannomutase 2 (PMM2) wild-type in apo state
Method: X-RAY DIFFRACTION / Resolution: 2.8 Å

PDB-7o1b:
Human phosphomannomutase 2 (PMM2) wild-type co-crystallized with the activator glucose 1,6-bisphosphate
Method: X-RAY DIFFRACTION / Resolution: 3.08 Å

PDB-7o4g:
Human phosphomannomutase 2 (PMM2) wild-type soaked with the activator glucose 1,6-bisphosphate
Method: X-RAY DIFFRACTION / Resolution: 2.66 Å

PDB-7o58:
Human phosphomannomutase 2 (PMM2) with mutation T237M in complex with the activator glucose 1,6-bisphosphate
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-7o5z:
Human phosphomannomutase 2 (PMM2) with mutation T237M in apo state
Method: X-RAY DIFFRACTION / Resolution: 2.07 Å

Chemicals

ChemComp-MG:
Unknown entry

ChemComp-NA:
Unknown entry

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-G16:
1,6-di-O-phosphono-alpha-D-glucopyranose

ChemComp-GOL:
GLYCEROL

Source
  • homo sapiens (human)
KeywordsISOMERASE / glycobiology / congenital disorders of glycosylation / phosphotransferase / phosphomutase

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