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-Structure paper
Title | Human RIPK3 maintains MLKL in an inactive conformation prior to cell death by necroptosis. |
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Journal, issue, pages | Nat Commun, Vol. 12, Page 6783-6783, Year 2021 |
Publish date | May 3, 2021 (structure data deposition date) |
Authors | Meng, Y. / Davies, K.A. / Fitzgibbon, C. / Young, S.N. / Garnish, S.E. / Horne, C.R. / Luo, C. / Garnier, J.M. / Liang, L.Y. / Cowan, A.D. ...Meng, Y. / Davies, K.A. / Fitzgibbon, C. / Young, S.N. / Garnish, S.E. / Horne, C.R. / Luo, C. / Garnier, J.M. / Liang, L.Y. / Cowan, A.D. / Samson, A.L. / Lessene, G. / Sandow, J.J. / Czabotar, P.E. / Murphy, J.M. |
External links | Nat Commun / PubMed:34811356 |
Methods | X-ray diffraction |
Resolution | 2.23 - 3.23 Å |
Structure data | PDB-7mon: PDB-7mx3: |
Chemicals | ChemComp-ZL1: ChemComp-HOH: ChemComp-ZOV: ChemComp-EDO: |
Source |
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Keywords | TRANSFERASE / pseudokinase / kinase / complex / necroptosis / TRANSFERASE/INHIBITOR / TRANSFERASE-INHIBITOR complex |