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-Structure paper
| Title | Discovery of a first-in-class reversible DNMT1-selective inhibitor with improved tolerability and efficacy in acute myeloid leukemia. |
|---|---|
| Journal, issue, pages | Nat Cancer, Vol. 2, Page 1002-1017, Year 2021 |
| Publish date | Jun 2, 2020 (structure data deposition date) |
 Authors | Pappalardi, M.B. / Keenan, K. / Cockerill, M. / Kellner, W.A. / Stowell, A. / Sherk, C. / Wong, K. / Pathuri, S. / Briand, J. / Steidel, M. ...Pappalardi, M.B. / Keenan, K. / Cockerill, M. / Kellner, W.A. / Stowell, A. / Sherk, C. / Wong, K. / Pathuri, S. / Briand, J. / Steidel, M. / Chapman, P. / Groy, A. / Wiseman, A.K. / McHugh, C.F. / Campobasso, N. / Graves, A.P. / Fairweather, E. / Werner, T. / Raoof, A. / Butlin, R.J. / Rueda, L. / Horton, J.R. / Fosbenner, D.T. / Zhang, C. / Handler, J.L. / Muliaditan, M. / Mebrahtu, M. / Jaworski, J.P. / McNulty, D.E. / Burt, C. / Eberl, H.C. / Taylor, A.N. / Ho, T. / Merrihew, S. / Foley, S.W. / Rutkowska, A. / Li, M. / Romeril, S.P. / Goldberg, K. / Zhang, X. / Kershaw, C.S. / Bantscheff, M. / Jurewicz, A.J. / Minthorn, E. / Grandi, P. / Patel, M. / Benowitz, A.B. / Mohammad, H.P. / Gilmartin, A.G. / Prinjha, R.K. / Ogilvie, D. / Carpenter, C. / Heerding, D. / Baylin, S.B. / Jones, P.A. / Cheng, X. / King, B.W. / Luengo, J.I. / Jordan, A.M. / Waddell, I. / Kruger, R.G. / McCabe, M.T. |
 External links | PubMed:34790902 |
| Methods | X-ray diffraction |
| Resolution | 1.79 - 2.65 Å |
| Structure data |  PDB-6x9i:  PDB-6x9j:  PDB-6x9k: |
| Chemicals |  ChemComp-SAH:  ChemComp-ZN:  ChemComp-EDO:  ChemComp-GOL:  ChemComp-HOH:  ChemComp-X52:  ChemComp-UXM: |
| Source |
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 Keywords | TRANSFERASE / EPIGENETICS / DNA METHYLTRANSFERASE FOLD / MAINTENANCE METHYLATION / TRANSFERASE/TRANSFERASE INHIBITOR/DNA / INHIBITION / TRANSFERASE-TRANSFERASE INHIBITOR complex / TRANSFERASE-TRANSFERASE INHIBITOR-DNA complex |
homo sapiens (human)