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TitleA Structural Basis for Inhibition of the Complement Initiator Protease C1r by Lyme Disease Spirochetes.
Journal, issue, pagesJ Immunol., Vol. 207, Page 2856-2867, Year 2021
Publish dateMay 24, 2021 (structure data deposition date)
AuthorsGarrigues, R.J. / Powell-Pierce, A.D. / Hammel, M. / Skare, J.T. / Garcia, B.L.
External linksJ Immunol. / PubMed:34759015
MethodsX-ray diffraction
Resolution4.07 Å
Structure data

PDB-7mzt:
Borrelia burgdorferi BBK32-C in complex with an autolytic fragment of human C1r at 4.1A
Method: X-RAY DIFFRACTION / Resolution: 4.07 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

Source
  • borrelia burgdorferi (strain atcc 35210 / b31 / cip 102532 / dsm 4680) (bacteria)
  • homo sapiens (human)
KeywordsPROTEIN BINDING / Lyme disease spirochete / Borrelia burgdorferi / complement system / classical pathway / protease inhibitor

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