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TitleMutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A beta-lactamase.
Journal, issue, pagesFebs Lett., Vol. 595, Page 2981-2994, Year 2021
Publish dateAug 31, 2021 (structure data deposition date)
AuthorsKemp, M.T. / Nichols, D.A. / Zhang, X. / Defrees, K. / Na, I. / Renslo, A.R. / Chen, Y.
External linksFebs Lett. / PubMed:34704263
MethodsX-ray diffraction
Resolution1.95 Å
Structure data

PDB-7s0v:
The role of an Asp-Asp pair in the structure, function and inhibition of CTX-M Class A Beta-lactamase
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-J1X:
3-(1H-pyrazol-1-yl)-N-[3-(1H-tetrazol-5-yl)phenyl]-5-(trifluoromethyl)benzamide

ChemComp-HOH:
WATER

Source
  • escherichia coli (E. coli)
KeywordsHYDROLASE/HYDROLASE inhibitor / Inhibitor / Complex / Asp-Asp / HYDROLASE / HYDROLASE-HYDROLASE inhibitor complex

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