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TitleDNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Journal, issue, pagesCancer Commun (Lond), Vol. 41, Page 1116-1136, Year 2021
Publish dateJan 15, 2021 (structure data deposition date)
AuthorsZhang, H. / Cheng, N. / Li, Z. / Bai, L. / Fang, C. / Li, Y. / Zhang, W. / Dong, X. / Jiang, M. / Liang, Y. ...Zhang, H. / Cheng, N. / Li, Z. / Bai, L. / Fang, C. / Li, Y. / Zhang, W. / Dong, X. / Jiang, M. / Liang, Y. / Zhang, S. / Mi, J. / Zhu, J. / Zhang, Y. / Chen, S.J. / Zhao, Y. / Weng, X.Q. / Hu, W. / Chen, Z. / Huang, J. / Meng, G.
External linksCancer Commun (Lond) / PubMed:34699692
MethodsX-ray diffraction
Resolution2.83 Å
Structure data

PDB-7dw5:
Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites
Method: X-RAY DIFFRACTION / Resolution: 2.83 Å

Chemicals

ChemComp-BR:
BROMIDE ION

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsDNA BINDING PROTEIN/DNA / acute lymphoblastic leukemia / DUX4/IGH / ERGalt / Clamp-like transactivation / DUX4-Responsive-Element / alternative splicing / DNA BINDING PROTEIN / DNA BINDING PROTEIN-DNA complex

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