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Structure paper

TitleStructural basis of cytokine-mediated activation of ALK family receptors.
Journal, issue, pagesNature, Vol. 600, Page 143-147, Year 2021
Publish dateMar 17, 2021 (structure data deposition date)
AuthorsDe Munck, S. / Provost, M. / Kurikawa, M. / Omori, I. / Mukohyama, J. / Felix, J. / Bloch, Y. / Abdel-Wahab, O. / Bazan, J.F. / Yoshimi, A. / Savvides, S.N.
External linksNature / PubMed:34646012
MethodsX-ray diffraction
Resolution1.3 - 4.17 Å
Structure data

PDB-7nwz:
ALK:ALKAL2 complex
Method: X-RAY DIFFRACTION / Resolution: 4.17 Å

PDB-7nx0:
LTK:ALKAL1 complex stabilized by a Nanobody
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

PDB-7nx1:
TG domain of LTK
Method: X-RAY DIFFRACTION / Resolution: 1.3 Å

PDB-7nx2:
Unbound antigen-binding fragment (FAb) 324
Method: X-RAY DIFFRACTION / Resolution: 1.47 Å

PDB-7nx3:
Crystal structure of ALK in complex with Fab324
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

PDB-7nx4:
Crystal structure of the TG and EGF-like domains of ALK
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-NA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-TB:
TERBIUM(III) ION

ChemComp-BTB:
2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

ChemComp-SO4:
SULFATE ION

ChemComp-ZN:
Unknown entry

ChemComp-NI:
NICKEL (II) ION

Source
  • homo sapiens (human)
  • lama glama (llama)
  • mus musculus (house mouse)
KeywordsPROTEIN BINDING / Cell Surface Receptor Cytokine binding Cytokine receptor complex / Cell Surface Receptor Cytokine binding / Antibody

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