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TitleA highly potent antibody effective against SARS-CoV-2 variants of concern.
Journal, issue, pagesCell Rep, Vol. 37, Issue 2, Page 109814, Year 2021
Publish dateOct 12, 2021
AuthorsCraig Fenwick / Priscilla Turelli / Laurent Perez / Céline Pellaton / Line Esteves-Leuenberger / Alex Farina / Jérémy Campos / Erica Lana / Flurin Fiscalini / Charlène Raclot / Florence Pojer / Kelvin Lau / Davide Demurtas / Marc Descatoire / Victor S Joo / Mathilde Foglierini / Alessandra Noto / Rana Abdelnabi / Caroline S Foo / Laura Vangeel / Johan Neyts / Wenjuan Du / Berend-Jan Bosch / Geertruida Veldman / Pieter Leyssen / Volker Thiel / Roger LeGrand / Yves Lévy / Didier Trono / Giuseppe Pantaleo /
PubMed AbstractControl of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced ...Control of the ongoing SARS-CoV-2 pandemic is endangered by the emergence of viral variants with increased transmission efficiency, resistance to marketed therapeutic antibodies, and reduced sensitivity to vaccine-induced immunity. Here, we screen B cells from COVID-19 donors and identify P5C3, a highly potent and broadly neutralizing monoclonal antibody with picomolar neutralizing activity against all SARS-CoV-2 variants of concern (VOCs) identified to date. Structural characterization of P5C3 Fab in complex with the spike demonstrates a neutralizing activity defined by a large buried surface area, highly overlapping with the receptor-binding domain (RBD) surface necessary for ACE2 interaction. We further demonstrate that P5C3 shows complete prophylactic protection in the SARS-CoV-2-infected hamster challenge model. These results indicate that P5C3 opens exciting perspectives either as a prophylactic agent in immunocompromised individuals with poor response to vaccination or as combination therapy in SARS-CoV-2-infected individuals.
External linksCell Rep / PubMed:34599871 / PubMed Central
MethodsEM (single particle)
Resolution3.5 - 4.3 Å
Structure data

13190

7p40

EMDB-13190, PDB-7p40:
P5C3 is a potent fab neutralizer
Method: EM (single particle) / Resolution: 3.5 Å

EMDB-13265:
the local resolution of Fab p5c3.
Method: EM (single particle) / Resolution: 4.3 Å

13415

7phg

EMDB-13415, PDB-7phg:
MaP OF P5C3RBD Interface
Method: EM (single particle) / Resolution: 4.3 Å

Source
  • severe acute respiratory syndrome coronavirus 2
  • homo sapiens (human)
KeywordsVIRAL PROTEIN / spike / antibody / RBD

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