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TitleArchitecture of Dispatched, a Transmembrane Protein Responsible for Hedgehog Release.
Journal, issue, pagesFront Mol Biosci, Vol. 8, Page 701826, Year 2021
Publish dateSep 7, 2021
AuthorsYitian Luo / Guoyue Wan / Xuan Zhou / Qiuwen Wang / Yunbin Zhang / Juan Bao / Yao Cong / Yun Zhao / Dianfan Li /
PubMed AbstractThe evolutionarily conserved Hedgehog (Hh) signaling pathway is crucial for programmed cell differentiation and proliferation. Dispatched (Disp) is a 12-transmembrane protein that plays a critical ...The evolutionarily conserved Hedgehog (Hh) signaling pathway is crucial for programmed cell differentiation and proliferation. Dispatched (Disp) is a 12-transmembrane protein that plays a critical role in the Hedgehog (Hh) signaling pathway by releasing the dually lipidated ligand HhN from the membrane, a prerequisite step to the downstream signaling cascade. In this study, we focus on the Disp from water bear, a primitive animal known as the most indestructible on Earth. Using a zebrafish model, we show that the water bear homolog possesses the function of Disp. We have solved its structure to a 6.5-Å resolution using single-particle cryogenic electron microscopy. Consistent with the evolutional conservation of the pathway, the water bear Disp structure is overall similar to the previously reported structures of the fruit fly and human homologs. Although not revealing much detail at this resolution, the water bear Disp shows a different conformation compared to published structures, suggesting that they represent different functional snapshots.
External linksFront Mol Biosci / PubMed:34557519 / PubMed Central
MethodsEM (single particle)
Resolution6.5 Å
Structure data

31595

7fif

EMDB-31595, PDB-7fif:
Cryo-EM structure of the hedgehog release protein Disp from water bear (Hypsibius dujardini)
Method: EM (single particle) / Resolution: 6.5 Å

Source
  • hypsibius dujardini (invertebrata)
KeywordsMEMBRANE PROTEIN / cryo-EM / Dispatched / Hedgehog release / Hedgehog signaling / setrol sensing domain / water bear

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