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TitleGenetic and structural basis for SARS-CoV-2 variant neutralization by a two-antibody cocktail.
Journal, issue, pagesNat Microbiol, Vol. 6, Page 1233-1244, Year 2021
Publish dateDec 28, 2020 (structure data deposition date)
AuthorsDong, J. / Zost, S.J. / Greaney, A.J. / Starr, T.N. / Dingens, A.S. / Chen, E.C. / Chen, R.E. / Case, J.B. / Sutton, R.E. / Gilchuk, P. ...Dong, J. / Zost, S.J. / Greaney, A.J. / Starr, T.N. / Dingens, A.S. / Chen, E.C. / Chen, R.E. / Case, J.B. / Sutton, R.E. / Gilchuk, P. / Rodriguez, J. / Armstrong, E. / Gainza, C. / Nargi, R.S. / Binshtein, E. / Xie, X. / Zhang, X. / Shi, P.Y. / Logue, J. / Weston, S. / McGrath, M.E. / Frieman, M.B. / Brady, T. / Tuffy, K.M. / Bright, H. / Loo, Y.M. / McTamney, P.M. / Esser, M.T. / Carnahan, R.H. / Diamond, M.S. / Bloom, J.D. / Crowe Jr., J.E.
External linksNat Microbiol / PubMed:34548634
MethodsX-ray diffraction
Resolution2.5 - 3 Å
Structure data

PDB-7l7d:
Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibody AZD8895
Method: X-RAY DIFFRACTION / Resolution: 2.5 Å

PDB-7l7e:
Crystal structure of SARS-CoV-2 spike RBD in complex with human monoclonal antibodies AZD8895 and AZD1061
Method: X-RAY DIFFRACTION / Resolution: 3 Å

Chemicals

ChemComp-GOL:
GLYCEROL

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-HOH:
WATER

ChemComp-PO4:
PHOSPHATE ION

Source
  • homo sapiens (human)
  • severe acute respiratory syndrome coronavirus 2
KeywordsVIRAL PROTEIN/IMMUNE SYSTEM / SARS-CoV-2 / spike protein / receptor binding domain / human monoclonal antibody / VIRAL PROTEIN-IMMUNE SYSTEM complex

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