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| Title | Structural engineering of chimeric antigen receptors targeting HLA-restricted neoantigens. |
|---|---|
| Journal, issue, pages | Nat Commun, Vol. 12, Page 5271-5271, Year 2021 |
| Publish date | Oct 2, 2019 (structure data deposition date) |
Authors | Hwang, M.S. / Miller, M.S. / Thirawatananond, P. / Douglass, J. / Wright, K.M. / Hsiue, E.H. / Mog, B.J. / Aytenfisu, T.Y. / Murphy, M.B. / Aitana Azurmendi, P. ...Hwang, M.S. / Miller, M.S. / Thirawatananond, P. / Douglass, J. / Wright, K.M. / Hsiue, E.H. / Mog, B.J. / Aytenfisu, T.Y. / Murphy, M.B. / Aitana Azurmendi, P. / Skora, A.D. / Pearlman, A.H. / Paul, S. / DiNapoli, S.R. / Konig, M.F. / Bettegowda, C. / Pardoll, D.M. / Papadopoulos, N. / Kinzler, K.W. / Vogelstein, B. / Zhou, S. / Gabelli, S.B. |
External links | Nat Commun / PubMed:34489470 |
| Methods | X-ray diffraction |
| Resolution | 1.9 - 2.9 Å |
| Structure data | ![]() PDB-6uj7: ![]() PDB-6uj8: ![]() PDB-6uj9: ![]() PDB-7kgu: |
| Chemicals | ![]() ChemComp-K: ![]() ChemComp-NA: ![]() ChemComp-SO4: ![]() ChemComp-HOH: ![]() ChemComp-PEG: ![]() ChemComp-1PE: ![]() ChemComp-PGE: ![]() ChemComp-PG4: ![]() ChemComp-NHE: ![]() ChemComp-BTB: ![]() ChemComp-CL: ![]() ChemComp-GLY: |
| Source |
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Keywords | IMMUNE SYSTEM / HLA-B7 / MHC-I / immunotherapy / IDH2 / antibody / Fab / 2Q1 / IGG |
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homo sapiens (human)
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