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Structure paper

TitleDeciphering the substrate recognition mechanisms of the heparan sulfate 3- O -sulfotransferase-3.
Journal, issue, pagesRsc Chem Biol, Vol. 2, Page 1239-1248, Year 2021
Publish dateJun 26, 2020 (structure data deposition date)
AuthorsWander, R. / Kaminski, A.M. / Xu, Y. / Pagadala, V. / Krahn, J.M. / Pham, T.Q. / Liu, J. / Pedersen, L.C.
External linksRsc Chem Biol / PubMed:34458837
MethodsX-ray diffraction
Resolution1.55 - 2.34 Å
Structure data

PDB-6xkg:
Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with 6S sulfation
Method: X-RAY DIFFRACTION / Resolution: 1.55 Å

PDB-6xl8:
Crystal structure of 3-O-Sulfotransferase isoform 3 in complex with 8mer oligosaccharide with no 6S sulfation
Method: X-RAY DIFFRACTION / Resolution: 2.34 Å

Chemicals

ChemComp-NPO:
P-NITROPHENOL

ChemComp-A3P:
ADENOSINE-3'-5'-DIPHOSPHATE

ChemComp-NA:
Unknown entry

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-HOH:
WATER

ChemComp-IOD:
IODIDE ION

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / sulfotransferase / enzyme / PAPS / Heparan sulfate

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