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TitleA high-affinity human TCR-like antibody detects celiac disease gluten peptide-MHC complexes and inhibits T cell activation.
Journal, issue, pagesSci Immunol, Vol. 6, Year 2021
Publish dateJul 8, 2020 (structure data deposition date)
AuthorsFrick, R. / Hoydahl, L.S. / Petersen, J. / du Pre, M.F. / Kumari, S. / Berntsen, G. / Dewan, A.E. / Jeliazkov, J.R. / Gunnarsen, K.S. / Frigstad, T. ...Frick, R. / Hoydahl, L.S. / Petersen, J. / du Pre, M.F. / Kumari, S. / Berntsen, G. / Dewan, A.E. / Jeliazkov, J.R. / Gunnarsen, K.S. / Frigstad, T. / Vik, E.S. / Llerena, C. / Lundin, K.E.A. / Yaqub, S. / Jahnsen, J. / Gray, J.J. / Rossjohn, J. / Sollid, L.M. / Sandlie, I. / Loset, G.A.
External linksSci Immunol / PubMed:34417258
MethodsX-ray diffraction
Resolution2.4 Å
Structure data

PDB-6xp6:
3C11-DQ2-glia-a2 complex
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-IPA:
ISOPROPYL ALCOHOL / alkaloid*YM

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • triticum aestivum (bread wheat)
KeywordsPEPTIDE BINDING PROTEIN / Complex Antibody Human Leucocyte Antigen

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