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TitleStructural and biochemical insights into a hyperthermostable urate oxidase from Thermobispora bispora for hyperuricemia and gout therapy.
Journal, issue, pagesInt. J. Biol. Macromol., Vol. 188, Page 914-923, Year 2021
Publish dateJun 14, 2021 (structure data deposition date)
AuthorsChiu, Y.C. / Hsu, T.S. / Huang, C.Y. / Hsu, C.H.
External linksInt. J. Biol. Macromol. / PubMed:34403675
MethodsX-ray diffraction
Resolution1.6 - 2.16 Å
Structure data

PDB-7f2v:
Urate oxidase from Thermobispora bispora in apo form
Method: X-RAY DIFFRACTION / Resolution: 1.6 Å

PDB-7f2w:
TbUox in complex with uric acid
Method: X-RAY DIFFRACTION / Resolution: 2.16 Å

Chemicals

ChemComp-SO4:
SULFATE ION

ChemComp-DMS:
DIMETHYL SULFOXIDE / DMSO, precipitant*YM

ChemComp-HOH:
WATER

ChemComp-URC:
URIC ACID

Source
  • thermobispora bispora (strain atcc 19993 / dsm 43833 / cbs 139.67 / jcm 10125 / nbrc 14880 / r51) (bacteria)
KeywordsOXIDOREDUCTASE / uricase / urate oxidase

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