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Structure paper

TitleStructural and mechanistic insights into the Artemis endonuclease and strategies for its inhibition.
Journal, issue, pagesNucleic Acids Res., Vol. 49, Page 9310-9326, Year 2021
Publish dateDec 23, 2019 (structure data deposition date)
AuthorsYosaatmadja, Y. / Baddock, H.T. / Newman, J.A. / Bielinski, M. / Gavard, A.E. / Mukhopadhyay, S.M.M. / Dannerfjord, A.A. / Schofield, C.J. / McHugh, P.J. / Gileadi, O.
External linksNucleic Acids Res. / PubMed:34387696
MethodsX-ray diffraction
Resolution1.5 - 1.97 Å
Structure data

PDB-6tt5:
Crystal structure of DCLRE1C/Artemis
Method: X-RAY DIFFRACTION / Resolution: 1.5 Å

PDB-7abs:
Structure of human DCLRE1C/Artemis in complex with DNA - re-evaluation of 6WO0
Method: X-RAY DIFFRACTION / Resolution: 1.97 Å

PDB-7af1:
The structure of Artemis/SNM1C/DCLRE1C with 2 Zinc ions
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-7afs:
The structure of Artemis variant D37A
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-7afu:
The structure of Artemis variant H33A
Method: X-RAY DIFFRACTION / Resolution: 1.56 Å

PDB-7agi:
The structure of Artemis variant H35D
Method: X-RAY DIFFRACTION / Resolution: 1.7 Å

PDB-7apv:
Structure of Artemis/DCLRE1C/SNM1C in complex with Ceftriaxone
Method: X-RAY DIFFRACTION / Resolution: 1.95 Å

Chemicals

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-ZN:
Unknown entry

ChemComp-NI:
NICKEL (II) ION

ChemComp-HOH:
WATER

ChemComp-9F2:
Ceftriaxone / antibiotic*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE / Endonuclease / DNA repair / V(D)J recombination / NHEJ recombination / LYASE / Artemis / NHEJ / Nuclease / SNM1C / DCLRE1C

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