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TitlePARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity.
Journal, issue, pagesCancer Cell, Vol. 39, Page 1214-1226.e10, Year 2021
Publish dateNov 26, 2019 (structure data deposition date)
AuthorsGozgit, J.M. / Vasbinder, M.M. / Abo, R.P. / Kunii, K. / Kuplast-Barr, K.G. / Gui, B. / Lu, A.Z. / Molina, J.R. / Minissale, E. / Swinger, K.K. ...Gozgit, J.M. / Vasbinder, M.M. / Abo, R.P. / Kunii, K. / Kuplast-Barr, K.G. / Gui, B. / Lu, A.Z. / Molina, J.R. / Minissale, E. / Swinger, K.K. / Wigle, T.J. / Blackwell, D.J. / Majer, C.R. / Ren, Y. / Niepel, M. / Varsamis, Z.A. / Nayak, S.P. / Bamberg, E. / Mo, J.R. / Church, W.D. / Mady, A.S.A. / Song, J. / Utley, L. / Rao, P.E. / Mitchison, T.J. / Kuntz, K.W. / Richon, V.M. / Keilhack, H.
External linksCancer Cell / PubMed:34375612
MethodsX-ray diffraction
Resolution2.04 Å
Structure data

PDB-6v3w:
Human Poly(ADP-Ribose) Polymerase 12, Catalytic fragment with four point mutations in complex with RBN-2397
Method: X-RAY DIFFRACTION / Resolution: 2.04 Å

Chemicals

ChemComp-QO4:
5-{[(2S)-1-(3-oxo-3-{4-[5-(trifluoromethyl)pyrimidin-2-yl]piperazin-1-yl}propoxy)propan-2-yl]amino}-4-(trifluoromethyl)pyridazin-3(2H)-one

ChemComp-CL:
Unknown entry

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsTRANSFERASE / ADP-ribosyltransferase activity

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