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TitleA GPC2 antibody-drug conjugate is efficacious against neuroblastoma and small-cell lung cancer via binding a conformational epitope.
Journal, issue, pagesCell Rep Med, Vol. 2, Page 100344-100344, Year 2021
Publish dateApr 14, 2020 (structure data deposition date)
AuthorsRaman, S. / Buongervino, S.N. / Lane, M.V. / Zhelev, D.V. / Zhu, Z. / Cui, H. / Martinez, B. / Martinez, D. / Wang, Y. / Upton, K. ...Raman, S. / Buongervino, S.N. / Lane, M.V. / Zhelev, D.V. / Zhu, Z. / Cui, H. / Martinez, B. / Martinez, D. / Wang, Y. / Upton, K. / Patel, K. / Rathi, K.S. / Navia, C.T. / Harmon, D.B. / Li, Y. / Pawel, B. / Dimitrov, D.S. / Maris, J.M. / Julien, J.P. / Bosse, K.R.
External linksCell Rep Med / PubMed:34337560
MethodsX-ray diffraction
Resolution3.3 Å
Structure data

PDB-6wjl:
Crystal structure of Glypican-2 core protein in complex with D3 Fab
Method: X-RAY DIFFRACTION / Resolution: 3.3 Å

Source
  • homo sapiens (human)
  • lama glama (llama)
KeywordsOncoprotein/Immune System / Neuroblastoma / Oncoprotein / Proteoglycan / Therapeutic antibody / Oncoprotein-Immune System complex

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