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TitleStructures of HIV-1 Neutralizing Antibody 10E8 Delineate the Mechanistic Basis of Its Multi-Peak Behavior on Size-Exclusion Chromatography.
Journal, issue, pagesAntibodies, Vol. 10, Year 2021
Publish dateApr 8, 2021 (structure data deposition date)
AuthorsDo Kwon, Y. / Wang, X.E. / Bender, M.F. / Yang, R. / Li, Y. / McKee, K. / Rawi, R. / O'Dell, S. / Schneck, N.A. / Shaddeau, A. ...Do Kwon, Y. / Wang, X.E. / Bender, M.F. / Yang, R. / Li, Y. / McKee, K. / Rawi, R. / O'Dell, S. / Schneck, N.A. / Shaddeau, A. / Zhang, B. / Arnold, F.J. / Connors, M. / Doria-Rose, N.A. / Kwong, P.D. / Lei, Q.P.
External linksAntibodies / PubMed:34200826
MethodsX-ray diffraction
Resolution1.74 - 3.7 Å
Structure data

PDB-7mf7:
Crystal structure of antibody 10E8v4-P100gA Fab
Method: X-RAY DIFFRACTION / Resolution: 2 Å

PDB-7mf8:
Crystal structure of antibody 10E8v4-P100fA Fab in space group P6422
Method: X-RAY DIFFRACTION / Resolution: 2.2 Å

PDB-7mf9:
Crystal structure of antibody 10E8v4-P100fA Fab in space group C2
Method: X-RAY DIFFRACTION / Resolution: 3.7 Å

PDB-7mfa:
Crystal structure of antibody 10E8v4-P100fA+P100gA Fab
Method: X-RAY DIFFRACTION / Resolution: 2.4 Å

PDB-7mfb:
Crystal structure of antibody 10E8v4 Fab - light chain H31F variant
Method: X-RAY DIFFRACTION / Resolution: 1.74 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsIMMUNE SYSTEM / Monoclonal antibody 10E8 / MPER / cis-trans isomerization / size-exclusion chromatography

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